Molecular detection and analysis of dengue virus genetic diversity in North Sulawesi, Indonesia during 2022
نویسندگان
چکیده
Abstract. Datu AM, Natzir R, Yustisia I, Wahid Soraya GV, Kadir S. 2023. Molecular detection and analysis of dengue virus genetic diversity in North Sulawesi, Indonesia during 2022. Biodiversitas 24: 3407-3413. Dengue is a highly infectious disease caused by the virus, consisting four serotypes (DENV1-DENV4). The existence diverse genotypes an area significantly impacts degree virulence humans, clinical manifestation, epidemiology disease. Studying pivotal, especially dengue-endemic areas such as Sulawesi. This study was explorative research analyzing sequencing on C-PrM protein region to determine diversity. conducted children adults 3 health centers Indonesia, Of 137 sera samples from febrile patients with dengue-like symptoms, ten were confirmed positive for virus. Out samples, DENV1 dominant serotype, which 70%. followed 20% DENV2 10% DENV4. genotype each DENV1, DENV2, DENV4, respectively classified into cosmopolitan genotype, I new DENV4 reported provides latest data viruses surveillance Sulawesi must be continuously due circulation multiple this province.
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ژورنال
عنوان ژورنال: Biodiversitas
سال: 2023
ISSN: ['1412-033X', '2085-4722']
DOI: https://doi.org/10.13057/biodiv/d240636